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1

O2-03-04: Aph1B gamma-secretase generates long Abeta peptides and genetic ablation improves Alzheimer's disease phenotypes without affecting notch signaling in the mouse

Lutgarde Serneels, Jérôme Van Biervliet, Katleen Craessaerts, Tim Dejaegere, Katrien Horré, Tine Van Houtvin, Hermann Esselmann, Sabine Paul, Ben Sprangers, Raf Sciot, Lieve Moons, Mathias Jucker, Jen

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 62 KB

english, 2008

2

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

Dejaegere, T., Serneels, L., Schafer, M. K., Van Biervliet, J., Horre, K., Depboylu, C., Alvarez-Fischer, D., Herreman, A., Willem, M., Haass, C., Hoglinger, G. U., D'Hooge, R., De Strooper, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

3

Differential contribution of the three Aph1 genes to -secretase activity in vivo

Serneels, L., Dejaegere, T., Craessaerts, K., Horre, K., Jorissen, E., Tousseyn, T., Hebert, S., Coolen, M., Martens, G., Zwijsen, A., Annaert, W., Hartmann, D., De Strooper, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 685 KB

english, 2005

4

-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

Serneels, L., Van Biervliet, J., Craessaerts, K., Dejaegere, T., Horre, K., Van Houtvin, T., Esselmann, H., Paul, S., Schafer, M. K., Berezovska, O., Hyman, B. T., Sprangers, B., Sciot, R., Moons, L.,

Journal:

Year:

2009

Language:

english

File:

PDF, 861 KB

english, 2009

5

Self-associating peptides for modular bifunctional conjugation of tetramer macromolecules in living cells

Vigneron, Marc, Dietsch, Frank, Bianchetti, Laurent, Dejaegere, Annick, Nominé, Yves, Cordonnier, Agnes M., Zuber, Guy, Chatton, Bruno, Donzeau, Mariel

Journal:

Bioconjugate Chemistry

Year:

2019

Language:

english

File:

PDF, 905 KB

english, 2019

6

Pisa: A new model for the estimation of intermolecular interaction energies in the liquid state

A. Dejaegere, M. Claessens, M. Bardiaux, J. Reisse

Journal:

Bulletin des Sociétés Chimiques Belges

Year:

1988

Language:

english

File:

PDF, 133 KB

english, 1988

7

ChemInform Abstract: Mechanism of Alkaline Hydrolysis of Cyclic and Acyclic Sulfates: An ab initio Study with Solvation Correction.

Xabier Lopez, Annick Dejaegere, Martin Karplus

Journal:

Year:

1999

File:

PDF, 25 KB

1999

8

Force field parameters for the simulation of modified histone tails

Cédric Grauffel, Roland H. Stote, Annick Dejaegere

Journal:

Journal of Computational Chemistry

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

9

Interpretation of the solvent effect on the screening constant of Xe-129

M. Luhmer, A. Dejaegere, J. Reisse

Journal:

Magnetic Resonance in Chemistry

Year:

1989

Language:

english

File:

PDF, 230 KB

english, 1989

10

Thiourea: The antioxidant of choice for the purification of proteins from phenol-rich plant tissues

Edilbert Van Driessche, Sonia Beeckmans, Robert Dejaegere, Louis Kanarek

Journal:

Analytical Biochemistry

Year:

1984

Language:

english

File:

PDF, 383 KB

english, 1984

11

Study of NMR relaxation of xenon-131 in quadrupolar solvents

A Dejaegere, M Luhmer, M-L Stien, J Reisse

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 980 KB

english, 1969

12

Alkylation of bromobenzene with allyl acetate over zeolites: Influence of zeolite factors and reaction conditions on activity and selectivity

Kshudiram Mantri, Eileen Dejaegere, Gino V. Baron, Joeri F.M. Denayer

Journal:

Applied Catalysis A: General

Year:

2007

Language:

english

File:

PDF, 1.74 MB

english, 2007

13

Fluorescence studies of the photosynthetic induction period

Jerome L. Rosenberg, Tevfik Bigat, Stephan Dejaegere

Journal:

Biochimica et Biophysica Acta (BBA) - Specialized Section on Biophysical Subjects

Year:

1964

Language:

english

File:

PDF, 709 KB

english, 1964

14

Protein–protein recognition and interaction hot spots in an antigen–antibody complex: Free energy decomposition identifies “efficient amino acids”

Virginie Lafont, Michael Schaefer, Roland H. Stote, Danièle Altschuh, Annick Dejaegere

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 561 KB

english, 2007

15

Dynamics of β3 integrin I-like and hybrid domains: Insight from simulations on the mechanism of transition between open and closed forms

Thomas Gaillard, Annick Dejaegere, Roland H. Stote

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2009

Language:

english

File:

PDF, 764 KB

english, 2009

16

Structure-Based Design of Benzoxazoles as new Inhibitors for D-Alanyl – D-Alanine Ligase

Isabelle Tytgat, Stéphane Vandevuer, Isabelle Ortmans, Finton Sirockin, Evelina Colacino, Françoise Van Bambeke, Colette Duez, Jacques H. Poupaert, Paul M. Tulkens, Annick Dejaegere, Martine Prévost

Journal:

Molecular Informatics

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

17

Theoretical studies on the hydrolysis of phosphate diesters in the gas phase, solution, and RNase A

Xabier Lopez, Darrin M. York, Annick Dejaegere, Martin Karplus

Journal:

International Journal of Quantum Chemistry

Year:

2002

Language:

english

File:

PDF, 1.17 MB

english, 2002

18

Effects of loop conformation on pKa and ligand binding in DNA gyrase B

Martina Schechner, Annick P. Dejaegere, Roland H. Stote

Journal:

International Journal of Quantum Chemistry

Year:

2004

Language:

english

File:

PDF, 446 KB

english, 2004

19

Effect of the nitrogen form used in the growth medium (NO3−, NH4+) on alkaloid production inDatura stramoniumL.

K. Demeyer, R. Dejaegere

Journal:

Year:

1992

Language:

english

File:

PDF, 595 KB

english, 1992

20

The immuno-histochemical localization of lectin in pea seeds (Pisum sativumL.)

E. Driessche, G. Smets, R. Dejaegere, L. Kanarek

Journal:

Year:

1981

Language:

english

File:

PDF, 4.28 MB

english, 1981

21

Mechanism of ion uptake across barley roots

R. Dejaegere, L. Neirinckx, J. M. Stassart, V. Delegher

Journal:

Year:

1981

Language:

english

File:

PDF, 230 KB

english, 1981

22

Dynamic correlation networks in human peroxisome proliferator-activated receptor-γ nuclear receptor protein

Jeremy Fidelak, Silvia Ferrer, Michael Oberlin, Dino Moras, Annick Dejaegere, Roland H. Stote

Journal:

European Biophysics Journal

Year:

2010

Language:

english

File:

PDF, 660 KB

english, 2010

23

Functionality Maps of the ATP Binding Site of DNA Gyrase B: Generation of a Consensus Model of Ligand Binding

Schechner, Martina, Sirockin, Finton, Stote, Roland H., Dejaegere, Annick P.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 594 KB

english, 2004

24

Influence of the ion-balance in the growth medium on the yield and alkaloid content ofDatura stramoniumL.

K. Demeyer, R. Dejaegere

Journal:

Year:

1989

Language:

english

File:

PDF, 434 KB

english, 1989

25

Structure Activity Relationship by NMR and by Computer: A Comparative Study

Sirockin, Finton, Sich, Christian, Improta, Sabina, Schaefer, Michael, Saudek, Vladimir, Froloff, Nicolas, Karplus, Martin, Dejaegere, Annick

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 852 KB

english, 2002

26

Angiographic predictors of recurrence of restenosis after Wiktor stent implantation in native coronary arteries

Peter DeJaegere, Patrick W. Serruys, Michel Bertrand, Volker Wiegand, Jean Francois Marquis, Matthias Vrolicx, Jan Piessens, Bernard Valeix, Gisbert Kober, Hans Bonnier, Wolfgang Rutsch, Rainer Uebis

Journal:

The American Journal of Cardiology

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

27

Experience with CoreValve aortic valve replacement in patients for surgical aortic valve replacement

E Grube, U Gerckens, G Schuler, A Linke, R Bonan, PW Serruys, P Dejaegere, J Kovacs, P Den Heijer, M Labinaz, M Ruell, M Mullen, A Bosmans, N Moat, W Tymchak, B Benit

Journal:

Cardiovascular Revascularization Medicine

Year:

2008

Language:

english

File:

PDF, 49 KB

english, 2008

28

Alkylation of deactivated aromatic compounds on zeolites. Adsorption, deactivation and selectivity effects in the alkylation of bromobenzene and toluene with bifunctional alkylating agents

Sophie Van der Beken, Eileen Dejaegere, Kourosch A. Tehrani, Johan S. Paul, Pierre A. Jacobs, Gino V. Baron, Joeri F.M. Denayer

Journal:

Journal of Catalysis

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

29

The Effect of Total Mineral Dose and pH on Alkaloid Accumulation in Datura stramonium L.

Demeyer, K., Dejaegere, R.

Journal:

Journal of Herbs Spices & Medicinal Plants

Year:

1996

Language:

english

File:

PDF, 267 KB

english, 1996

30

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

Sara Cipolat, Tomasz Rudka, Dieter Hartmann, Veronica Costa, Lutgarde Serneels, Katleen Craessaerts, Kristine Metzger, Christian Frezza, Wim Annaert, Luciano D'Adamio, Carmen Derks, Tim Dejaegere, Luc

Journal:

Year:

2006

Language:

english

File:

PDF, 1.16 MB

english, 2006

31

Comparative Normal Mode Analysis of LFA-1 Integrin I-domains

Thomas Gaillard, Elyette Martin, Eider San Sebastian, Fernando P. Cossío, Xabier Lopez, Annick Dejaegere, Roland H. Stote

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 2.34 MB

english, 2007

32

Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

Sébastien S. Hébert, Lutgarde Serneels, Tim Dejaegere, Katrien Horré, Michal Dabrowski, Veerle Baert, Wim Annaert, Dieter Hartmann, Bart De Strooper

Journal:

Neurobiology of Disease

Year:

2004

Language:

english

File:

PDF, 576 KB

english, 2004

33

P2-075 APH1 knock-out mice

Lutgarde Serneels, Tim Dejaegere, Katleen Craessaerts, Katrien Horré, Sébastien Hébert, Ellen Jorissen, Dieter Hartmann, Bart De Strooper

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

34

Structure-Based Design of Short Peptide Ligands Binding onto the E. coli Processivity Ring

Wolff, Philippe, Oliéric, Vincent, Briand, Jean Paul, Chaloin, Olivier, Dejaegere, Annick, Dumas, Philippe, Ennifar, Eric, Guichard, Gilles, Wagner, Jérôme, Burnouf, Dominique Y.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

35

Phosphate ester hydrolysis: calculation of gas-phase reaction paths and solvation effects

Dejaegere, Annick, Liang, Xiaoling, Karplus, Martin

Journal:

Journal of the Chemical Society Faraday Transactions

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

36

Analysis of Coupling Schemes in Free Energy Simulations: A Unified Description of Nonbonded Contributions to Solvation Free Energies

Dejaegere, A., Karplus, M.

Journal:

Journal of Physical Chemistry

Year:

1996

Language:

english

File:

PDF, 844 KB

english, 1996

37

On the Affinity Regulation of the Metal-Ion-Dependent Adhesion Sites in Integrins

Sebastian, Eider San, Mercero, Jose M., Stote, Roland H., Dejaegere, Annick, Cossío, Fernando P., Lopez, Xabier

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 385 KB

english, 2006

38

Design, Synthesis, and Functional Evaluation of Leukocyte Function Associated Antigen-1 Antagonists in Early and Late Stages of Cancer Development

San Sebastián, Eider, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Sirockin, Finton, Dejaegere, Annick, Stote, Roland H., Lopez, Xabier, Pantoja-Uceda, David, Valcárcel, María, Mendoza

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.45 MB

english, 2013

39

Protein/Ligand Binding Free Energies Calculated with Quantum Mechanics/Molecular Mechanics

Gräter, Frauke, Schwarzl, Sonja M., Dejaegere, Annick, Fischer, Stefan, Smith, Jeremy C.

Journal:

Journal of Physical Chemistry B

Year:

2005

Language:

english

File:

PDF, 190 KB

english, 2005

40

Structural and Dynamic Characterization of ω-Conotoxin MVIIA: The Binding Loop Exhibits Slow Conformational Exchange †,‡

Atkinson, R. Andrew, Kieffer, Bruno, Dejaegere, Annick, Sirockin, Finton, Lefèvre, Jean-François

Journal:

Year:

2000

Language:

english

File:

PDF, 298 KB

english, 2000

41

Modeling of Toluene Acetylation with Acetic Anhydride on H-USY Zeolite

Dejaegere, Eileen A., Thybaut, Joris W., Marin, Guy B., Baron, Gino V., Denayer, Joeri F. M.

Journal:

Industrial & Engineering Chemistry Research

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

42

Protein Structural Statistics with PSS

Gaillard, Thomas, Schwarz, Benjamin B. L., Chebaro, Yassmine, Stote, Roland H., Dejaegere, Annick

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 2.31 MB

english, 2013

43

Hydrolysis rate difference between cyclic and acyclic phosphate esters: solvation versus strain

Dejaegere, Annick, Karplus, Martin

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 301 KB

english, 1993

44

Challenges in p K a Predictions for Proteins: The case of Asp213 in Human Proteinase 3 †

Hajjar, Eric, Dejaegere, Annick, Reuter, Nathalie

Journal:

Journal of Physical Chemistry A

Year:

2009

Language:

english

File:

PDF, 3.27 MB

english, 2009

45

Proton extrusion and ion uptake: Some characteristics of the phenomenon in barley seedlings

Dejaegere, Robert, Neirinckx, Louis

Journal:

Zeitschrift für Pflanzenphysiologie

Year:

1978

Language:

english

File:

PDF, 1.06 MB

english, 1978

46

Metal Ion Dependent Adhesion Sites in Integrins: A Combined DFT and QMC Study on Mn 2+

San Sebastian, Eider, Matxain, Jon M., Eriksson, Leif A., Stote, Roland H., Dejaegere, Annick, Cossio, Fernando P., Lopez, Xabier

Journal:

Journal of Physical Chemistry B

Year:

2007

Language:

english

File:

PDF, 73 KB

english, 2007

47

Structural Insights into the Molecular Mechanism of Vitamin D Receptor Activation by Lithocholic Acid Involving a New Mode of Ligand Recognition

Belorusova, Anna Y., Eberhardt, Jérôme, Potier, Noëlle, Stote, Roland H., Dejaegere, Annick, Rochel, Natacha

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.08 MB

english, 2014

48

Variations in Antigen−Antibody Association Kinetics as a Function of pH and Salt Concentration: A QSAR and Molecular Modeling Study †

Dejaegere, Annick, Choulier, Laurence, Lafont, Virginie, De Genst, Erwin, Altschuh, Danièle

Journal:

Year:

2005

Language:

english

File:

PDF, 407 KB

english, 2005

49

Theoretical Evaluation of p K a in Phosphoranes: Implications for Phosphate Ester Hydrolysis

Lopez, Xabier, Schaefer, Michael, Dejaegere, Annick, Karplus, Martin

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 218 KB

english, 2002

50

Structural Basis for the Accommodation of Bis- and Tris-Aromatic Derivatives in Vitamin D Nuclear Receptor

Ciesielski, Fabrice, Sato, Yoshiteru, Chebaro, Yassmine, Moras, Dino, Dejaegere, Annick, Rochel, Natacha

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.88 MB

english, 2012

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